Changes in hemodynamic parameters, inotropic state, and myocardial oxygen consumption owing to intravenous application of nitroglycerin
نویسندگان
چکیده
منابع مشابه
Hemodynamic dependence of myocardial oxygen consumption indexes.
We tested the afterload and contractile state dependency of three indexes of myocardial oxygen consumption (MVO2): total energy requirement (Et), pressure work index (PWI), and pressure-volume area (PVA). MVO2 was measured in seven isolated canine hearts at four or five different end-diastolic volumes at each of three settings of afterload resistance and with the hearts contracting isovolumical...
متن کاملNitroglycerin reduces myocardial oxygen consumption during exercise despite vascular tolerance.
The long-term benefits of nitroglycerin (NTG) therapy are limited by the development of vascular tolerance and endothelial dysfunction in conductance coronary arteries. We have determined whether nitrate tolerance extends to NTG effects on myocardial O2 consumption (MV(O2)) and the ability of endogenous nitric oxide (NO) to modulate MV(O2) during exercise. In chronically instrumented dogs (n = ...
متن کاملThe Hemodynamic Effects of Drugs on Myocardial Oxygen Use
The circulatory responses to high equinalgesic doses of morphine are compared with those of pethidin. The decrease in mean arterial blood pressure in case of morphine was 28p.c., with a paralleled and identical decrease in total peripheral resistance and no negative inotropic effects. Pethidine decreased blood pressure 54p.c., as a result of peripheral vasodilation of 46p.c. and a sharp drop...
متن کاملIntravenous Nitroglycerin in Acute Myocardial Infarction
Vasodilator therapy has been shown to improve ventricular function in patients with left ventricular failure complicating acute myocardial infarction. Sublingual nitroglycerin also improves ventricular function in these patients but its effects are transient and variable. Infusion of intravenous nitroglycerin in 12 patients with acute infarction resulted in a decrease in left ventricular fillin...
متن کاملIntravenous nitroglycerin in acute myocardial infarction.
Until recently, the use of nitroglycerin in patients with acute myocardial infarction has been contraindicated primarily because of possible hypotension or tachycardia which, with sublingual or oral preparations, would be difficult to control. The introduction of intravenous nitroglycerin and its use during experimentally induced infarction paved the way for its use in patients with acute myoca...
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ژورنال
عنوان ژورنال: The Journal of Thoracic and Cardiovascular Surgery
سال: 1977
ISSN: 0022-5223
DOI: 10.1016/s0022-5223(19)41441-4